Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates

• Main Authors: J.S. Dileep Kumar (Author), Matthew S. Milak (Author), Vattoly J. Majo (Author), Jaya Prabhakaran (Author), Pratap Mali (Author), Lyudmila Savenkova (Author), J. John Mann (Author), Ramin V. Parsey (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Serotonin (5-HT) 1A receptors exist in high and low affinity states. Agonist ligands bind preferentially to the high affinity state receptors, providing a more functionally relevant measure than antagonist binding. We now report comparison of 5-HT1A binding in vivo using both [11C]CUMI-101 (agonist)...