Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease

• Main Authors: Sopak Supakul (Author), Rei Murakami (Author), Chisato Oyama (Author), Tomoko Shindo (Author), Yuki Hatakeyama (Author), Maika Itsuno (Author), Hiroko Bannai (Author), Shinsuke Shibata (Author), Sumihiro Maeda (Author), Hideyuki Okano (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The development of induced pluripotent stem cells (iPSCs) technology has enabled human cellular disease modeling for inaccessible cell types, such as neural cells in the brain. However, many of the iPSC-derived disease models established to date typically involve only a single ce...