Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability

• Prif Awduron: Jing Shi (Awdur), Rui Ju (Awdur), Hongting Gao (Awdur), Yuqing Huang (Awdur), Lei Guo (Awdur), Dechang Zhang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2022-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Tumor cells have unique metabolic programming that is biologically distinct from that of corresponding normal cells. Resetting tumor metabolic programming is a promising strategy to ameliorate drug resistance and improve the tumor microenvironment. Here, we show that carboxyamidotriazole (CAI), an a...