Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis

Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays a crucial role in the synthesis of cell wall arabinan components in mycobacteria, including the pathogen responsible for tuberculosis, Mycobacterium tuberculosis. In this stud...

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Main Authors: Manisha Singh (Author), Sarah M. Batt (Author), Christian S. C. Canales (Author), Fernando R. Pavan (Author), Sethu Arun Kumar (Author), Handattu S. Akshatha (Author), Meduri Bhagyalalitha (Author), Karthik G. Pujar (Author), Durgesh Bidye (Author), Gurubasavaraj V. Pujar (Author), Gurdyal S. Besra (Author)
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Publicado em: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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