Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis

• Ngā kaituhi matua: Manisha Singh (Author), Sarah M. Batt (Author), Christian S. C. Canales (Author), Fernando R. Pavan (Author), Sethu Arun Kumar (Author), Handattu S. Akshatha (Author), Meduri Bhagyalalitha (Author), Karthik G. Pujar (Author), Durgesh Bidye (Author), Gurubasavaraj V. Pujar (Author), Gurdyal S. Besra (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays a crucial role in the synthesis of cell wall arabinan components in mycobacteria, including the pathogen responsible for tuberculosis, Mycobacterium tuberculosis. In this stud...