Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis

• Main Authors: Manisha Singh (Author), Sarah M. Batt (Author), Christian S. C. Canales (Author), Fernando R. Pavan (Author), Sethu Arun Kumar (Author), Handattu S. Akshatha (Author), Meduri Bhagyalalitha (Author), Karthik G. Pujar (Author), Durgesh Bidye (Author), Gurubasavaraj V. Pujar (Author), Gurdyal S. Besra (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays a crucial role in the synthesis of cell wall arabinan components in mycobacteria, including the pathogen responsible for tuberculosis, Mycobacterium tuberculosis. In this stud...