Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers

• Main Authors: Huimin Wu (Author), Yuchen Xu (Author), Mengru Cai (Author), Longtai You (Author), Jing Liu (Author), Xiaoxv Dong (Author), Xingbin Yin (Author), Jian Ni (Author), Changhai Qu (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The incidence of ocular surface disease (OSD) is increasing, with a trend towards younger ages. However, it is difficult for drugs to reach the deep layers of the cornea due to ocular surface barriers, and bioavailability is less than 5%. In this study, DSPE-PEG2000 was modified with L-valine (L-Val...