Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers

• Autors principals: Huimin Wu (Autor), Yuchen Xu (Autor), Mengru Cai (Autor), Longtai You (Autor), Jing Liu (Autor), Xiaoxv Dong (Autor), Xingbin Yin (Autor), Jian Ni (Autor), Changhai Qu (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-06-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The incidence of ocular surface disease (OSD) is increasing, with a trend towards younger ages. However, it is difficult for drugs to reach the deep layers of the cornea due to ocular surface barriers, and bioavailability is less than 5%. In this study, DSPE-PEG2000 was modified with L-valine (L-Val...