A single intraarticular injection of a tranexamic acid-modified hyaluronic acid (HA/TXA) alleviates pain and reduces OA development in a murine model of monosodium iodoacetate-induced osteoarthritis

• Main Authors: Sybille Brochard (Author), Karim Boumédiene (Author), Jéromine Mercier (Author), Véronique Agin (Author), Thierry Conrozier (Author), Catherine Baugé (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

RationaleTranexamic acid (TXA) is a strong and specific plasminogen activator inhibitor with inhibitory effects on the matrix metalloproteases involved in the pathophysiology of osteoarthritis (OA) through targeting of the fibrinolysis pathway. In this study, we evaluated the analgesic and chondropr...