Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25−FOXP3+ Cells

• Main Authors: Vanessa Carregaro (Author), Marcelo H. Napimoga (Author), Raphael S. Peres (Author), Luciana Benevides (Author), Laís Amorim Sacramento (Author), Larissa G. Pinto (Author), Renata Grespan (Author), Thiago M. Cunha (Author), João Santana da Silva (Author), Fernando Q. Cunha (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prostaglandin, 15-deoxy Δ12,14-prostaglandin J2 (15d-PGJ2), is a lipid mediator that plays an important role in the control of chronic inflammatory disease. However, the role of prostanoid in rheumatoid arthritis (RA) is not well determined. We demonstrated the therapeutic effect of 15d-PGJ2 in...