24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer's Disease

• Автори: Gabriella Testa (Автор), Serena Giannelli (Автор), Barbara Sottero (Автор), Erica Staurenghi (Автор), Giorgio Giaccone (Автор), Paola Caroppo (Автор), Paola Gamba (Автор), Gabriella Leonarduzzi (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer's disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-hydroxycholesterol (24-OHC) has recently...