Nobiletin protects against alcohol-induced mitochondrial dysfunction and liver injury by regulating the hepatic NRF1-TFAM signaling pathway

• Main Authors: Dan Lu (Author), Aiping Huang (Author), Xiaoqing Tong (Author), Xiaoyan Zhang (Author), Songtao Li (Author), Xiaolong Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives Alcohol and its metabolites, such as acetaldehyde, induced hepatic mitochondrial dysfunction play a pathological role in the development of alcohol-related liver disease (ALD).Methods In this study, we investigated the potential of nobiletin (NOB), a polymethoxylated flavone, to counter a...