Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.

• Κύριοι συγγραφείς: James Watson (Συγγραφέας), Walter R J Taylor (Συγγραφέας), Germana Bancone (Συγγραφέας), Cindy S Chu (Συγγραφέας), Podjanee Jittamala (Συγγραφέας), Nicholas J White (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given...