Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.

• Hoofdauteurs: James Watson (Auteur), Walter R J Taylor (Auteur), Germana Bancone (Auteur), Cindy S Chu (Auteur), Podjanee Jittamala (Auteur), Nicholas J White (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given...