Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.

• Main Authors: James Watson (Author), Walter R J Taylor (Author), Germana Bancone (Author), Cindy S Chu (Author), Podjanee Jittamala (Author), Nicholas J White (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given...