Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

• Auteurs principaux: Kaijun Jin (Auteur), Minjie Liu (Auteur), Chunlin Zhuang (Auteur), Erik De Clercq (Auteur), Christophe Pannecouque (Auteur), Ge Meng (Auteur), Fener Chen (Auteur)
• Format: Livre
• Publié: Elsevier, 2020-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is presented. These compounds exhibited excellent pot...