Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

• Váldodahkkit: Kaijun Jin (Dahkki), Minjie Liu (Dahkki), Chunlin Zhuang (Dahkki), Erik De Clercq (Dahkki), Christophe Pannecouque (Dahkki), Ge Meng (Dahkki), Fener Chen (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2020-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is presented. These compounds exhibited excellent pot...