Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

• 主要な著者: Rubens Monte-Neto (著者), Marie-Claude N Laffitte (著者), Philippe Leprohon (著者), Priscila Reis (著者), Frédéric Frézard (著者), Marc Ouellette (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

BACKGROUND:Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS:Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromosoma...