Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

• Main Authors: Rubens Monte-Neto (Author), Marie-Claude N Laffitte (Author), Philippe Leprohon (Author), Priscila Reis (Author), Frédéric Frézard (Author), Marc Ouellette (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS:Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromosoma...