Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

• Главные авторы: Rubens Monte-Neto (Автор), Marie-Claude N Laffitte (Автор), Philippe Leprohon (Автор), Priscila Reis (Автор), Frédéric Frézard (Автор), Marc Ouellette (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Предметы: article
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BACKGROUND:Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS:Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromosoma...