Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

• Príomhchruthaitheoirí: Rubens Monte-Neto (Údar), Marie-Claude N Laffitte (Údar), Philippe Leprohon (Údar), Priscila Reis (Údar), Frédéric Frézard (Údar), Marc Ouellette (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

BACKGROUND:Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS:Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromosoma...