Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

• Hoofdauteurs: Rubens Monte-Neto (Auteur), Marie-Claude N Laffitte (Auteur), Philippe Leprohon (Auteur), Priscila Reis (Auteur), Frédéric Frézard (Auteur), Marc Ouellette (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2015-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

BACKGROUND:Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS:Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromosoma...