A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats

• Main Authors: Xiaowan Han (Author), Shiqiang Gong (Author), Ni Li (Author), Xiao Wang (Author), Peng Liu (Author), Yanni Xu (Author), Xiaobo He (Author), Wei Jiang (Author), Shuyi Si (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ratio of osteoprotegerin (OPG) to the receptor activator of NF-κB ligand (RANKL) is a key determinant in the regulation of bone metabolism. The study was performed to screen novel anti-osteoporotic drugs regulating OPG/RANKL ratio and evaluate their effect on bone metabolism. According to the sc...