Activation of dopamine receptor D1 promotes osteogenic differentiation and reduces glucocorticoid-induced bone loss by upregulating the ERK1/2 signaling pathway

• Main Authors: Jie Zhu (Author), Chengcheng Feng (Author), Weicheng Zhang (Author), Zhidong Wang (Author), Mengdan Zhong (Author), Wenkai Tang (Author), Zhifang Wang (Author), Haiwei Shi (Author), Zhengyu Yin (Author), Jiandong Shi (Author), Yu Huang (Author), Long Xiao (Author), Dechun Geng (Author), Zhirong Wang (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The inhibition of osteogenic differentiation is a major factor in glucocorticoid-induced bone loss, but there is currently no effective treatment. Dopamine, a major neurotransmitter, transmits signals via five different seven-transmembrane G protein-coupled receptors termed D1 to...