Rational design of heat stable lyophilized rotavirus vaccine formulations

• Principais autores: Madhu Madan (Autor), Deepa Sikriwal (Autor), Gaurav Sharma (Autor), Nidhi Shukla (Autor), Ashwani Kumar Mandyal (Autor), Sachin Kale (Autor), Davinder Gill (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2018-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

To develop a safe and efficacious heat-stable rotavirus vaccine, new lyophilized formulations were developed using rotavirus serotypes constituting RotaTeq®. A series of formulation compositions, differing in buffering agents, bulking agents, cryoprotectants, amino acids and divalent cations, were s...