Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of Chd7 from the Embryonic Mid-Hindbrain Region

• Ngā kaituhi matua: Alex P. A. Donovan (Author), Tian Yu (Author), Jacob Ellegood (Author), Kimberley L. H. Riegman (Author), Christa de Geus (Author), Conny van Ravenswaaij-Arts (Author), Cathy Fernandes (Author), Jason P. Lerch (Author), M. Albert Basson (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Reduced fibroblast growth factor (FGF) signaling from the mid-hindbrain or isthmus organizer (IsO) during early embryonic development results in hypoplasia of the midbrain and cerebellar vermis. We previously reported evidence for reduced Fgf8 expression and FGF signaling in the mid-hindbrain region...