Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo

• Główni autorzy: Xiangxi Kong (Autor), Yajin Liao (Autor), Lujun Zhou (Autor), Ying Zhang (Autor), Jinbo Cheng (Autor), Zengqiang Yuan (Autor), Shukun Wang (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Activation of the NLRP3 inflammasome results in caspase 1 cleavage, which subsequently leads to IL-1β and IL-18 secretion, as well as pyroptosis, and aberrant activation of the inflammasome is involved in several diseases such as type 2 diabetes, atherosclerosis, multiple sclerosis, Parkinson's...