TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V mutation

• প্রধান লেখক: Ying Shen (লেখক), Xiaoyue Wei (লেখক), Shijie Jin (লেখক), Yue Wu (লেখক), Wenbin Zhao (লেখক), Yingchun Xu (লেখক), Liqiang Pan (লেখক), Zhan Zhou (লেখক), Shuqing Chen (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Limited clinical application of antibody-drug conjugates (ADCs) targeting tumor associated antigens (TAAs) is usually caused by on-target off-tumor side effect. Tumor-specific mutant antigens (TSMAs) only expressed in tumor cells which are ideal targets for ADCs. In addition, intracellular somatic m...