TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V mutation

• Main Authors: Ying Shen (Author), Xiaoyue Wei (Author), Shijie Jin (Author), Yue Wu (Author), Wenbin Zhao (Author), Yingchun Xu (Author), Liqiang Pan (Author), Zhan Zhou (Author), Shuqing Chen (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Limited clinical application of antibody-drug conjugates (ADCs) targeting tumor associated antigens (TAAs) is usually caused by on-target off-tumor side effect. Tumor-specific mutant antigens (TSMAs) only expressed in tumor cells which are ideal targets for ADCs. In addition, intracellular somatic m...