Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells

• Main Authors: Guangya Xu (Author), Xueling Yan (Author), Zhongjia Hu (Author), Lulu Zheng (Author), Ke Ding (Author), Yamei Zhang (Author), Yi Qing (Author), Tao Liu (Author), Lijia Cheng (Author), Zheng Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucocappasalin (GCP), a natural product derived from the seeds of Descurainia sophia (L.) Webb. ex Prantl, exhibits potential antitumor activity in HeLa cervical carcinoma cells. In this study, we investigated the anti-cervical cancer property of GCP through the induction of cell cycle arrest, apop...