A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells

• Váldodahkkit: Ola Karmi (Dahkki), Yang-Sung Sohn (Dahkki), Henri-Baptiste Marjault (Dahkki), Tal Israeli (Dahkki), Gil Leibowitz (Dahkki), Konstantinos Ioannidis (Dahkki), Yaakov Nahmias (Dahkki), Ron Mittler (Dahkki), Ioav Z. Cabantchik (Dahkki), Rachel Nechushtai (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Decreased insulin secretion, associated with pancreatic β-cell failure, plays a critical role in many human diseases including diabetes, obesity, and cancer. While numerous studies linked β-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated wit...