Evidence for a peak shift in a humoral response to helminths: age profiles of IgE in the Shuar of Ecuador, the Tsimane of Bolivia, and the U.S. NHANES.
The peak shift model predicts that the age-profile of a pathogen's prevalence depends upon its transmission rate, peaking earlier in populations with higher transmission and declining as partial immunity is acquired. Helminth infections are associated with increased immunoglobulin E (IgE), whic...
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Main Authors: | Aaron D Blackwell (Author), Michael D Gurven (Author), Lawrence S Sugiyama (Author), Felicia C Madimenos (Author), Melissa A Liebert (Author), Melanie A Martin (Author), Hillard S Kaplan (Author), J Josh Snodgrass (Author) |
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Format: | Book |
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Public Library of Science (PLoS),
2011-06-01T00:00:00Z.
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