Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of nifedipine-betacyclodextrin complexes

• Main Authors: Swati Changdeo Jagdale (Author), Vinayak Narhari Jadhav (Author), Aniruddha Rajaram Chabukswar (Author), Bhanudas Shankar Kuchekar (Author)
• Format: Book
• Published: Universidade de São Paulo, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main objective of the study was to enhance the dissolution of nifedipine, a poorly water soluble drug by betacyclodextrin complexation and to study the effect of the preparation method on the in vitro dissolution profile. The stoichiometric ratio determined by phase solubility analysis for inclu...