Folium Sennae Increased the Bioavailability of Methotrexate through Modulation on MRP 2 and BCRP

• Main Authors: Chung-Ping Yu (Author), Yu-Hsuan Peng (Author), Ching-Ya Huang (Author), Yow-Wen Hsieh (Author), Yu-Chi Hou (Author), Shiuan-Pey Lin (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Folium Sennae (FS), a popular laxative (Senna), contains polyphenolic anthranoids, whose conjugation metabolites are probable modulators of multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP). We suspected that the combined use of FS might alter the pharmacoki...