Folium Sennae Increased the Bioavailability of Methotrexate through Modulation on MRP 2 and BCRP

• Auteurs principaux: Chung-Ping Yu (Auteur), Yu-Hsuan Peng (Auteur), Ching-Ya Huang (Auteur), Yow-Wen Hsieh (Auteur), Yu-Chi Hou (Auteur), Shiuan-Pey Lin (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Folium Sennae (FS), a popular laxative (Senna), contains polyphenolic anthranoids, whose conjugation metabolites are probable modulators of multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP). We suspected that the combined use of FS might alter the pharmacoki...