Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis

• Hoofdauteurs: Nimita Dave (Auteur), Sathej Gopalakrishnan (Auteur), Sven Mensing (Auteur), Ahmed Hamed Salem (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wiley, 2019-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Venetoclax is an approved drug for the treatment of some hematological malignancies. Venetoclax can cause reduction in B‐lymphocyte counts as an on‐target effect. The purpose of this analysis is to quantify the relationship between venetoclax exposure and B‐lymphocyte levels to inform dosing of vene...