Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis

• Main Authors: Nimita Dave (Author), Sathej Gopalakrishnan (Author), Sven Mensing (Author), Ahmed Hamed Salem (Author)
• Formato: Libro
• Publicado: Wiley, 2019-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Venetoclax is an approved drug for the treatment of some hematological malignancies. Venetoclax can cause reduction in B‐lymphocyte counts as an on‐target effect. The purpose of this analysis is to quantify the relationship between venetoclax exposure and B‐lymphocyte levels to inform dosing of vene...