Expression of Endothelial NOX5 Alters the Integrity of the Blood-Brain Barrier and Causes Loss of Memory in Aging Mice

• Main Authors: Adriana Cortés (Author), Maite Solas (Author), Álvaro Pejenaute (Author), Miguel A. Abellanas (Author), Marcos Garcia-Lacarte (Author), Maria S. Aymerich (Author), Javier Marqués (Author), María J. Ramírez (Author), Guillermo Zalba (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blood-Brain barrier (BBB) disruption is a hallmark of central nervous system (CNS) dysfunction, and oxidative stress is one of the molecular mechanisms that may underlie this process. NADPH oxidases (NOX) are involved in oxidative stress-mediated vascular dysfunction and participate in the pathophys...