Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

• Váldodahkkit: Todd M Pitts (Dahkki), Gillian N Kulikowski (Dahkki), Aik-Choon eTan (Dahkki), Brion William Murray (Dahkki), John J Arcaroli (Dahkki), John J Tentler (Dahkki), Anna eSpreafico (Dahkki), Heather M Selby (Dahkki), Maria I Kachaeva (Dahkki), Kelly L McPhillips (Dahkki), Blair C Britt (Dahkki), Erica Lynn Bradshaw-Pierce (Dahkki), Wells A Messersmith (Dahkki), Marileila eVarella-Garcia (Dahkki), S. Gail eEckhardt (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2013-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The p21-activated kinase (PAK) family of serine/threonine kinases, which are overexpressed in several cancer types, are critical mediators of cell survival, motility, mitosis, transcription, and translation. In the study presented here we utilized a panel of CRC cell lines to identify potential biom...