Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

• Egile Nagusiak: Todd M Pitts (Egilea), Gillian N Kulikowski (Egilea), Aik-Choon eTan (Egilea), Brion William Murray (Egilea), John J Arcaroli (Egilea), John J Tentler (Egilea), Anna eSpreafico (Egilea), Heather M Selby (Egilea), Maria I Kachaeva (Egilea), Kelly L McPhillips (Egilea), Blair C Britt (Egilea), Erica Lynn Bradshaw-Pierce (Egilea), Wells A Messersmith (Egilea), Marileila eVarella-Garcia (Egilea), S. Gail eEckhardt (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2013-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The p21-activated kinase (PAK) family of serine/threonine kinases, which are overexpressed in several cancer types, are critical mediators of cell survival, motility, mitosis, transcription, and translation. In the study presented here we utilized a panel of CRC cell lines to identify potential biom...