Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

• Main Authors: Todd M Pitts (Author), Gillian N Kulikowski (Author), Aik-Choon eTan (Author), Brion William Murray (Author), John J Arcaroli (Author), John J Tentler (Author), Anna eSpreafico (Author), Heather M Selby (Author), Maria I Kachaeva (Author), Kelly L McPhillips (Author), Blair C Britt (Author), Erica Lynn Bradshaw-Pierce (Author), Wells A Messersmith (Author), Marileila eVarella-Garcia (Author), S. Gail eEckhardt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The p21-activated kinase (PAK) family of serine/threonine kinases, which are overexpressed in several cancer types, are critical mediators of cell survival, motility, mitosis, transcription, and translation. In the study presented here we utilized a panel of CRC cell lines to identify potential biom...