Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

• मुख्य लेखकों: Todd M Pitts (लेखक), Gillian N Kulikowski (लेखक), Aik-Choon eTan (लेखक), Brion William Murray (लेखक), John J Arcaroli (लेखक), John J Tentler (लेखक), Anna eSpreafico (लेखक), Heather M Selby (लेखक), Maria I Kachaeva (लेखक), Kelly L McPhillips (लेखक), Blair C Britt (लेखक), Erica Lynn Bradshaw-Pierce (लेखक), Wells A Messersmith (लेखक), Marileila eVarella-Garcia (लेखक), S. Gail eEckhardt (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2013-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The p21-activated kinase (PAK) family of serine/threonine kinases, which are overexpressed in several cancer types, are critical mediators of cell survival, motility, mitosis, transcription, and translation. In the study presented here we utilized a panel of CRC cell lines to identify potential biom...