Cover Image

Panax notoginseng saponins inhibits NLRP3 inflammasome-mediated pyroptosis by downregulating lncRNA-ANRIL in cardiorenal syndrome type 4

Abstract Objective Cardiorenal syndrome type 4 (CRS4) is a complication of chronic kidney disease. Panax notoginseng saponins (PNS) have been confirmed to be efficient in cardiovascular diseases. Our study aimed to explore the therapeutic role and mechanism of PNS in CRS4. Methods CRS4 model rats an...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ying Xu (Author), Luxi Cao (Author), Wenli Zou (Author), Rizhen Yu (Author), Wei Shen (Author)
Format:	Book
Published:	BMC, 2023-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Saponin accumulation in the seedling root of <it>Panax notoginseng</it>
by: Zhang Yingjun, et al.
Published: (2011)

Pustular drug eruption due to Panax notoginseng saponins
by: Yin ZQ, et al.
Published: (2014)

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review
by: Ming Peng, et al.
Published: (2018)

High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq
by: Junyun Cheng, et al.
Published: (2023)

Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
by: Guangfei Wei, et al.
Published: (2018)

Eight darmarane-type saponins isolated from the roots of Panax notoginseng
by: Kaunda Joseph Sakah, et al.
Published: (2013)

Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss
by: Xuelian Zhang, et al.
Published: (2021)

Panax notoginseng Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview
by: Lian Duan, et al.
Published: (2017)

Effect of Panax notoginseng Saponins on Focal Cerebral Ischemia-Reperfusion in Rat Models: A Meta-Analysis
by: Tao Sun, et al.
Published: (2021)

Panax notoginseng saponins prevent dementia and oxidative stress in brains of SAMP8 mice by enhancing mitophagy
by: Yingying Yang, et al.
Published: (2024)

Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway
by: Peiqi Zhu, et al.
Published: (2021)

Panax notoginseng Saponins Alleviate Coronary Artery Disease Through Hypermethylation of the miR-194-MAPK Pathway
by: Lian Duan, et al.
Published: (2022)

Efficacy and Safety of Panax Notoginseng Saponins (Xueshuantong) in Patients With Acute Ischemic Stroke (EXPECT) Trial: Rationale and Design
by: Luda Feng, et al.
Published: (2021)

Anti-platelet aggregation of Panax notoginseng triol saponins by regulating GP1BA for ischemic stroke therapy
by: Zhi-yi Xu, et al.
Published: (2021)

Saponins from Panax notoginseng ameliorate steroid resistance in lupus nephritis through regulating lymphocyte-derived exosomes in mice
by: Jia Chen, et al.
Published: (2022)

Personalized bioconversion of Panax notoginseng saponins mediated by gut microbiota between two different diet-pattern healthy subjects
by: Li Wang, et al.
Published: (2021)

Downregulation of ATP1A1 Expression by Panax notoginseng (Burk.) F.H. Chen Saponins: A Potential Mechanism of Antitumor Effects in HepG2 Cells and In Vivo
by: Xiao-Yi Feng, et al.
Published: (2021)

The use of Panax notoginseng saponins injections after intravenous thrombolysis in acute ischemic stroke: a systematic review and meta-analysis
by: Yaoyuan Liu, et al.
Published: (2024)

Steamed Panax notoginseng and its Saponins Inhibit the Migration and Induce the Apoptosis of Neutrophils in a Zebrafish Tail-Fin Amputation Model
by: Yin Xiong, et al.
Published: (2022)

Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins
by: Jiajia Dong, et al.
Published: (2021)

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach
by: Zongxi Sun, et al.
Published: (2021)

Comparative study on saponin fractions from <it>Panax notoginseng </it>inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion
by: Deng Yan-Hui, et al.
Published: (2011)

The lncRNA ANRIL Gene rs2151280 GG Genotype is Associated with Increased Susceptibility to Recurrent Miscarriage in a Southern Chinese Population
by: Che D, et al.
Published: (2021)

Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1
by: Mariam Ali Abo-Saif, et al.
Published: (2023)

Identification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers
by: Wenzhi Yang, et al.
Published: (2016)

NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention
by: Ping Ding, et al.
Published: (2024)

Panax Notoginseng Saponins Protect Cardiac Myocytes Against Endoplasmic Reticulum Stress and Associated Apoptosis Through Mediation of Intracellular Calcium Homeostasis
by: Jun Chen, et al.
Published: (2019)

Preparation, optimization, and in vivo evaluation of an inhaled solution of total saponins of Panax notoginseng and its protective effect against idiopathic pulmonary fibrosis
by: Mengjiao Liu, et al.
Published: (2020)

Panax notoginseng extract and total saponin suppress diet-induced obesity and endoplasmic reticulum stress in epididymal white adipose tissue in mice
by: Yi Tan, et al.
Published: (2022)

Simultaneous determination of three major bioactive saponins of <it>Panax notoginseng </it>using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study
by: Zhu Chunyan, et al.
Published: (2010)

Multi-layered effects of Panax notoginseng on immune system
by: Chunhao Yang, et al.
Published: (2024)

Panax notoginseng Saponins Stimulates Neurogenesis and Neurological Restoration After Microsphere-Induced Cerebral Embolism in Rats Partially Via mTOR Signaling
by: Jiale Gao, et al.
Published: (2022)

Efficacy and safety of Panax notoginseng saponin injection in the treatment of acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials
by: Pengfei Chen, et al.
Published: (2024)

Efficacy and safety of Panax notoginseng saponins (Xuesaitong) for patients with acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials
by: Xinyi Shi, et al.
Published: (2023)

Role of Porphyromonas gingivalis in the downregulation of NLRp3 inflammasome in periodontitis
by: Neelam Gavali, et al.
Published: (2022)

LncRNA MHRT Prevents Angiotensin II-Induced Myocardial Oxidative Stress and NLRP3 Inflammasome via Nrf2 Activation
by: Pinyi Liu, et al.
Published: (2023)

Effect of Spray Drying Conditions on Physical Properties of Panax notoginseng Saponin (PNS) Powder and the Intra-Batch Dissolution Variability of PNS Hydrophilic Matrix Tablet
by: Yang M, et al.
Published: (2021)

Composition and function of rhizosphere microbiome of Panax notoginseng with discrepant yields
by: Mengzhi Li, et al.
Published: (2020)

Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation
by: Mei-Yu Shen, et al.
Published: (2023)

Allelic and Genotypic Analysis of LncRNA ANRIL rs4977574 A/G Mutations in Oral Squamous Cell Carcinoma Patients: Insights into Tumor Characteristics and Genotypic Correlations
by: Mohammad Amin Amiri, et al.
Published: (2023)