A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

• Ngā kaituhi matua: Hitesh eMistry (Author), Mark Richard Davies (Author), Giovanni Y Di Veroli (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac...