A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

• Main Authors: Hitesh eMistry (Author), Mark Richard Davies (Author), Giovanni Y Di Veroli (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Fag: article
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There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac...