Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

• Main Authors: Bloom Aaron P (Author), Mantyh William G (Author), Jimenez-Andrade Juan M (Author), Freeman Katie T (Author), Ghilardi Joseph R (Author), Kuskowski Michael A (Author), Mantyh Patrick W (Author)
• Format: Book
• Published: SAGE Publishing, 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Pain often accompanies cancer and most current therapies for treating cancer pain have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomyosin receptor kinase A (TrkA) has become an attractive target for attenuat...