Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants

• Main Authors: Lu Wang (Author), Chin-Yi Chu (Author), Matthew N. McCall (Author), Christopher Slaunwhite (Author), Jeanne Holden-Wiltse (Author), Anthony Corbett (Author), Ann R. Falsey (Author), David J. Topham (Author), Mary T. Caserta (Author), Thomas J. Mariani (Author), Edward E. Walsh (Author), Xing Qiu (Author)
• Format: Book
• Published: BMC, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background A substantial number of infants infected with RSV develop severe symptoms requiring hospitalization. We currently lack accurate biomarkers that are associated with severe illness. Method We defined airway gene expression profiles based on RNA sequencing from nasal brush samples f...