Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase

• Main Authors: Jihyun Kang (Author), Andrew HyoungJin Kim (Author), Inseung Jeon (Author), Jaeseong Oh (Author), In‐Jin Jang (Author), SeungHwan Lee (Author), Joo‐Youn Cho (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Five‐fluorouracil (5‐FU) is a chemotherapeutic agent that is mainly metabolized by the rate‐limiting enzyme dihydropyrimidine dehydrogenase (DPD). The DPD enzyme activity deficiency involves a wide range of severities. Previous studies have demonstrated the effect of a DPYD single nucleotid...