Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold

• 主要な著者: Tiphanie Pruvost (著者), Magali Mathieu (著者), Steven Dubois (著者), Bernard Maillère (著者), Emmanuelle Vigne (著者), Hervé Nozach (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

ABSTRACTDelineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold standard for providing precise information about these binding sit...