Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold

• Päätekijät: Tiphanie Pruvost (Tekijä), Magali Mathieu (Tekijä), Steven Dubois (Tekijä), Bernard Maillère (Tekijä), Emmanuelle Vigne (Tekijä), Hervé Nozach (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

ABSTRACTDelineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold standard for providing precise information about these binding sit...