Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold

• Asıl Yazarlar: Tiphanie Pruvost (Yazar), Magali Mathieu (Yazar), Steven Dubois (Yazar), Bernard Maillère (Yazar), Emmanuelle Vigne (Yazar), Hervé Nozach (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

ABSTRACTDelineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold standard for providing precise information about these binding sit...