Monte Carlo Thompson sampling-guided design for antibody engineering

• Main Authors: Taro Kakuzaki (Author), Hikaru Koga (Author), Shuuki Takizawa (Author), Shoichi Metsugi (Author), Hirotake Shiraiwa (Author), Zenjiro Sampei (Author), Kenji Yoshida (Author), Hiroyuki Tsunoda (Author), Reiji Teramoto (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAntibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their sequence space. However, it is practica...