Monte Carlo Thompson sampling-guided design for antibody engineering

• Váldodahkkit: Taro Kakuzaki (Dahkki), Hikaru Koga (Dahkki), Shuuki Takizawa (Dahkki), Shoichi Metsugi (Dahkki), Hirotake Shiraiwa (Dahkki), Zenjiro Sampei (Dahkki), Kenji Yoshida (Dahkki), Hiroyuki Tsunoda (Dahkki), Reiji Teramoto (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

ABSTRACTAntibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their sequence space. However, it is practica...