Monte Carlo Thompson sampling-guided design for antibody engineering

• Autori principali: Taro Kakuzaki (Autore), Hikaru Koga (Autore), Shuuki Takizawa (Autore), Shoichi Metsugi (Autore), Hirotake Shiraiwa (Autore), Zenjiro Sampei (Autore), Kenji Yoshida (Autore), Hiroyuki Tsunoda (Autore), Reiji Teramoto (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ABSTRACTAntibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their sequence space. However, it is practica...