Low Protective Efficacy of the Current Japanese Encephalitis Vaccine against the Emerging Genotype 5 Japanese Encephalitis Virus.

• Main Authors: Lei Cao (Author), Shihong Fu (Author), Xiaoyan Gao (Author), Minghua Li (Author), Shiheng Cui (Author), Xiaolong Li (Author), Yuxi Cao (Author), Wenwen Lei (Author), Zhi Lu (Author), Ying He (Author), Huanyu Wang (Author), Jinghua Yan (Author), George Fu Gao (Author), Guodong Liang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The current Japanese encephalitis (JE) vaccine derived from G3 JE virus (JEV) can induce protective immunity against G1-G4 JEV genotypes. However, protective efficacy against the emerging G5 genotype has not been reported.Using in vitro and in vivo tests, biological phenotype and cross-immunoreactio...