Recent advances of sorafenib nanoformulations for cancer therapy: Smart nanosystem and combination therapy

• Главные авторы: Fangmin Chen (Автор), Yifan Fang (Автор), Xiang Chen (Автор), Rui Deng (Автор), Yongjie Zhang (Автор), Jingwei Shao (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2021-05-01T00:00:00Z.
• Предметы: article
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Sorafenib, a molecular targeted multi-kinase inhibitor, has received considerable interests in recent years due to its significant profiles of efficacy in cancer therapy. However, poor pharmacokinetic properties such as limited water solubility, rapid elimination and metabolism lead to low bioavaila...