Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

• Главные авторы: Christopher B. Lietz (Автор), Ekaterina Deyanova (Автор), Younhee Cho (Автор), Jon Cordia (Автор), Sarah Franc (Автор), Sally Kabro (Автор), Steven Wang (Автор), David Mikolon (Автор), Douglas D. Banks (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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ABSTRACTDespite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell...