Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

• Main Authors: Christopher B. Lietz (Author), Ekaterina Deyanova (Author), Younhee Cho (Author), Jon Cordia (Author), Sarah Franc (Author), Sally Kabro (Author), Steven Wang (Author), David Mikolon (Author), Douglas D. Banks (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

ABSTRACTDespite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell...