Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity

• Hauptverfasser: Christopher B. Lietz (Verfasst von), Ekaterina Deyanova (Verfasst von), Younhee Cho (Verfasst von), Jon Cordia (Verfasst von), Sarah Franc (Verfasst von), Sally Kabro (Verfasst von), Steven Wang (Verfasst von), David Mikolon (Verfasst von), Douglas D. Banks (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

ABSTRACTDespite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell...