The road to evolution of ProTx2: how to be a subtype-specific inhibition of human Nav1.7

• Váldodahkkit: Fan Zhao (Dahkki), Yuanyuan Liu (Dahkki), Yiyu Liu (Dahkki), Qi Ye (Dahkki), Hongtao Yang (Dahkki), Mingze Gui (Dahkki), Yongbo Song (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The human voltage-gated sodium channel Nav1.7 is a widely proven target for analgesic drug studies. ProTx2, a 30-residue polypeptide from Peruvian green tarantula venom, shows high specificity to activity against human Nav1.7, suggesting its potential to become a non-addictive analgesic. However, it...