The road to evolution of ProTx2: how to be a subtype-specific inhibition of human Nav1.7

The human voltage-gated sodium channel Nav1.7 is a widely proven target for analgesic drug studies. ProTx2, a 30-residue polypeptide from Peruvian green tarantula venom, shows high specificity to activity against human Nav1.7, suggesting its potential to become a non-addictive analgesic. However, it...

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主要な著者: Fan Zhao (著者), Yuanyuan Liu (著者), Yiyu Liu (著者), Qi Ye (著者), Hongtao Yang (著者), Mingze Gui (著者), Yongbo Song (著者)
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出版事項: Frontiers Media S.A., 2024-05-01T00:00:00Z.
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