Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

ABSTRACTMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of M...

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Main Authors: Wenfeng Lin (Author), Jiaqi Xiong (Author), Yefan Jiang (Author), Hao Liu (Author), Jinhui Bian (Author), Juejin Wang (Author), Yongfeng Shao (Author), Buqing Ni (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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3rd Floor Main Library

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