Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

• Váldodahkkit: Wenfeng Lin (Dahkki), Jiaqi Xiong (Dahkki), Yefan Jiang (Dahkki), Hao Liu (Dahkki), Jinhui Bian (Dahkki), Juejin Wang (Dahkki), Yongfeng Shao (Dahkki), Buqing Ni (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

ABSTRACTMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of M...