Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

• Auteurs principaux: Wenfeng Lin (Auteur), Jiaqi Xiong (Auteur), Yefan Jiang (Auteur), Hao Liu (Auteur), Jinhui Bian (Auteur), Juejin Wang (Auteur), Yongfeng Shao (Auteur), Buqing Ni (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

ABSTRACTMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of M...